PUBLICATIONS

Protosequences in brain organoids model intrinsic brain states
van der Molen T., Spaeth A., Chini M., Hernandez S., Kaurala G.A., Schweiger H.E., Duncan C., McKenna S., Geng J., Lim M., Bartram J., Dendukuri A., Zhang Z., Gonzalez-Ferrer J., Bhaskaran-Nair K., Blauvelt L.J., Harder C.R.K., Petzold L.R., Alam El Din D.-M., Laird J., Schenke M., Smirnova L., Colquitt B.M., Mostajo-Radji M.A., Hansma P.K., Teodorescu M., Hierlemann A., Hengen K.B., Hanganu-Opatz I.L., Kosik K.S., Sharf T.
Nat Neurosci., in press 

Hippocampus facilitates reinforcement learning under partial observability
Pedamonti D., Mohinta S., Dimitrov M.V., Malagon-Vina H., Ciocchi S., Ponte Costa R.
Nat Commun., in press 

Formation of Task Representations and Replay in Mouse Medial Prefrontal Cortex
Shabani H., Muysers H., Yiu Y.-H., Sauer J.-F., Bartos M., Leibold C.
eLife 2025 Jul 25;16(1):5383.doi:10.7554/eLife.106981.1.

Numerosity coding in the brain: from early visual processing to abstract representations
Nieder, A.
Cereb Cortex. 2025 Jul 1;35(7):bhaf180.doi:10.1093/cercor/bhaf180.

Abstract rule learning promotes cognitive flexibility in complex environments across species
Bähner F., Popov T., Boehme N., Hermann S., Merten T., Zingone H., Koppe G., Meyer-Lindberg A., Toutounji H. & Durstewitz D.
Nat Commun. 2025 Jun 25;16(1):5396.doi:10.1038/s41467-025-60943-7.

Predictive goal coding by dentate gyrus somatostatin-expressing interneurons in male mice
Yuan M., Cazala A., Goedeke S., Leibold C., Sauer J.-F. & Bartos M.
Nat Commun. 2025 Jun 25;16(1):5383.doi:10.1038/s41467-025-60841-y.

The dorsal and ventral hippocampus contribute differentially to spatial working memory and spatial coding in the prefrontal cortex
Babl S. S. & Sigurdsson T.
PLoS Biol. 2025 Apr 23;23(4):e3003140.doi:10.1371/journal.pbio.3003140.

Conjoint generalized and trajectory-specific coding of task structure by prefrontal neurons
Muysers H., Bartos M. & Sauer J.-F.
Cell Rep. 2025 Mar 8;44(3):115420. doi:10.1016/j.celrep.2025.115420.

Neuronal mechanisms enhancing selectivity of the innate number sense via learning 
Nieder, A.
Cereb Cortex. 2025 Feb 5;35(2):bhaf019.doi:10.1093/cercor/bhaf019.

Trajectories of working memory and decision making abilities along juvenile development in mice 
Thies A.M., Pochinok I., Marquardt A., Hardung S., Dorofeikova M., Hanganu-Opatz I.L. & Pöpplau J.A.
Front Neurosci. 2025 Feb 5;19:3389. doi:10.3389/fnins.2025.1524931.

The Calculating Brain
Nieder A.
Physiological Reviews. 2025 Jan 1;105(1):267-314. doi: 10.1152/physrev.00014.2024.

A Retrospective Report of Carprofen Administration as Post-Operative Analgesia Reveals Negative Effects of Recommended Doses
Jäckel Z., Adzemovic A., Kloos B., Hardung S., Sanchez-Brandelik R., Coulon P.  & Diester I.
Animals (Basel). 2024 Nov 4;14(21):3157. doi: 10.3390/ani14213157.

Freilaser: Flexible Pulse Generator for Laser Control in Optogenetic Experiments
Schneider A., Diester I.
SSRN. 2024 Nov. doi: 10.2139/ssrn.5022052.

Low rate hippocampal delay period activity encodes behavioral experience
Athanasiadis M., Masserini S., Yuan L., Fetterhoff D., Leutgeb J. K., Leutgeb S. & Leibold C.
Hippocampus. 2024 Jun 5. doi: 10.1002/hipo.23619.

Preconfigured architecture of the developing mouse brain
Chini M., Hnida M., Kostka J. K., Chen Y. & Hanganu-Opatz I. L.
Cell Rep. 2024 May 24;43(6):114267. doi: 10.1016/j.celrep.2024.114267.

Bifurcations and loss jumps in RNN training
Eisenmann L., Monfared Z., Göring N. & Durstewitz D.
NeurIPS. 2024 Apr;36(1).

A persistent prefrontal reference frame across time and task rules
Muysers H., Chen H.-L., Hahn J., Folschweiller S., Sigurdsson T., Sauer J.-F. & Bartos M.
Nat Commun. 2024 Mar 8;15(1):2115. doi: 10.1038/s41467-024-46350-4.

Sequential neuronal processing of number values, abstract decision, and action in the primate prefrontal cortex
Viswanathan P., Stein A. & Nieder A.
PLoS Biol. 2024 Feb 16;22(2):e3002520. doi: 10.1371/journal.pbio.3002520. eCollection 2024 Feb.

Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels
Jammal Salameh L., Bitzenhofer S.H., Hanganu-Opatz I. L., Dutschmann M., Egger V.
Science. 2024 Feb 2;383(6682):eadk8511. doi: 10.1126/science.adk8511. Epub 2024 Feb 2.

A developmental increase of inhibition promotes the emergence of hippocampal ripples
Pochinok I., Stöber T. M., Triesch J., Chini M. & Hanganu-Opatz I. L.
Nat Commun. 2024 Jan 25;15(1):738. doi: 10.1038/s41467-024-44983-z.

Neuronal tuning to threat exposure remains stable in the mouse prefrontal cortex over multiple days
Sylte O.C., Muysers H., Chen H.-L., Bartos M. & Sauer J-F.
PLoS Biol. 2024 Jan 11;22(1):e3002475. doi: 10.1371/journal.pbio.3002475. eCollection 2024 Jan

The neuronal implementation of representational geometry in primate prefrontal cortex
Lin X., Nieder A. & Jacob S.N.
Sci Adv. 2023 Dec 15;9(50):eadh8685. doi: 10.1126/sciadv.adh8685. Epub 2023 Dec 13.

Convergent Circuit Computation for Categorization in the Brains of Primates and Songbirds
Nieder A.
Cold Spring Harb Perspect Biol. 2023 Dec 1;15(12):a041526. doi: 10.1101/cshperspect.a041526

Dopamine receptor activation regulates reward expectancy signals during cognitive control in primate prefrontal neurons
Ott T., Stein A.M. & Nieder A.
Nat Commun. 2023 Nov 20;14(1):7537. doi: 10.1038/s41467-023-43271-6.

Reorganization of adolescent prefrontal cortex circuitry is required for mouse cognitive maturation
Pöpplau J.A., Schwarze T., Dorofeikova M., Pochinok I., Günther A., Marquardt A. & Hanganu-Opatz I.L.
Neuron. 2023 Nov 8:S0896-6273(23)00805-X. doi: 10.1016/j.neuron.2023.10.024

Reconstructing computational system dynamics from neural data with recurrent neural networks
Durstewitz D., Koppe G. & Thurm M.I.
Nat Rev Neurosci. 2023 Nov;24(11):693-710. doi: 10.1038/s41583-023-00740-7.

Olfactory bulb activity shapes the development of entorhinal-hippocampal coupling and associated cognitive abilities.

Chen Y.N., Kostka J.K., Bitzenhofer S.H. & Hanganu-Opatz I.L.
Curr Biol. 2023 Sep 13:S0960-9822(23)01152-1. doi: 10.1016/j.cub.2023.08.072.

Olfactory-driven beta band entrainment of limbic circuitry during neonatal development
Kostka J.K. & Hanganu-Opatz I.L.
J Physiol. 2023 Aug;601(16):3605-3630. doi: 10.1113/JP284401.

Differential behavior-related activity of distinct hippocampal interneuron types during odor-associated spatial navigation
Forro T. & Klausberger T.
Neuron. 2023 Jun 1;S0896-6273(23)00380-X. doi: 10.1016/j.neuron.2023.05.007.

Behavioral state-dependent modulation of prefrontal cortex activity by respiration
Folschweiller S. & Sauer J.-F.
J Neurosc. 2023 Jun 5; JN-RM-2075-22. doi: 10.1523/JNEUROSCI.2075-22.2023.

FreiBox: A Versatile Open-Source Behavioral Setup for Investigating the Neuronal Correlates of Behavioral Flexibility via 1-Photon Imaging in Freely Moving Mice
De La Crompe B., Schneck M., Steenbergen F., Schneider A., Diester I.
eNeuro. 2023 Apr 27;10(4):ENEURO.0469-22.2023. doi: 10.1523/ENEURO.0469-22.2023.

Resolving the prefrontal mechanisms of adaptive cognitive behaviors: A cross-species perspective
Hanganu-Opatz I.L., Klausberger T., Sigurdsson T., Nieder A., Jacob S.N., Bartos M., Sauer J.-F., Durstewitz D., Leibold C., Diester I.
Neuron. 2023 Apr 5;111(7):1020-1036. doi: 10.1016/j.neuron.2023.03.017.

Conserved structures of neural activity in sensorimotor cortex of freely moving rats allow cross-subject decoding
Melbaum S., Russo E., Eriksson D., Schneider A., Durstewitz D., Brox T., Diester I.
Nat Commun. 2022 Dec 2;13(1):7420. doi: 10.1038/s41467-022-35115-6.

Disrupted-in-schizophrenia-1 is required for normal pyramidal cell–interneuron communication and assembly dynamics in the prefrontal cortex 
Sauer J.-F., Bartos M.
Elife. 2022 Oct 14;11:e79471. doi: 10.7554/eLife.79471.

Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice
Schepanski S., Chini M., Sternemann V., Urbschat C., Thiele K., Sun T., Zhao Y., Poburski M., Woestemeier A., Thieme M.T., Zazara D.E., Alawi M., Fischer N., Heeren J., Vladimirov N., Woehler A., Puelles V.G., Bonn S., Gagliani N., Hanganu-Opatz I.L., Arck P.C.
Nat Commun. 2022 Aug 5;13(1):4571. doi: 10.1038/s41467-022-32230-2.

3D pose estimation enables virtual head-fixation in freely moving rats
Schneider A., Zimmermann C., Alyahyay M., Steenbergen F., Brox T., Diester I.
Neuron. 2022 Jul 6;110(13):2080-2093.e10. doi: 10.1016/j.neuron.2022.04.019. Epub 2022 May 23.

Prefrontal pyramidal neurons are critical for all phases of working memory
Vogel P., Hahn J., Duvarci S., Sigurdsson T.
 Cell Rep. 2022 Apr 12;39(2):110659. doi: 10.1016/j.celrep.2022.110659.

Multichannel optogenetics combined with laminar recordings for ultra-controlled neuronal interrogation
Eriksson D., Schneider A., Thirumalai A., Alyahyay M., de la Crompe B., Sharma K., Ruther P., Diester I.
Nat Commun. 2022 Feb 21;13(1):985. doi: 10.1038/s41467-022-28629-6. 

Topographically organized representation of space and context in the medial prefrontal cortex
Sauer J.-F., Folschweiller S., Bartos M.
Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2117300119. doi: 10.1073/pnas.2117300119.

Introducing the Research Unit 5159 “Resolving the prefrontal circuits of cognitive flexibility
Hanganu-Opatz I.L., Diester I.
Neuroforum, Issue 01 2022