FreiBox: A Versatile Open-Source Behavioral Setup for Investigating the Neuronal Correlates of Behavioral Flexibility via 1-Photon Imaging in Freely Moving Mice
Resolving the prefrontal mechanisms of adaptive cognitive behaviors: A cross-species perspective
Conserved structures of neural activity in sensorimotor cortex of freely moving rats allow cross-subject decoding
Nat Commun. 2022 Dec 2;13(1):7420. doi: 10.1038/s41467-022-35115-6.
Our knowledge about neuronal activity in the sensorimotor cortex relies primarily on stereotyped movements that are strictly controlled in experimental settings. It remains unclear how results can be carried over to less constrained behavior like that of freely …
Disrupted-in-schizophrenia-1 is required for normal pyramidal cell–interneuron communication and assembly dynamics in the prefrontal cortex
Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice
Nat Commun. 2022 Aug 5;13(1):4571. doi: 10.1038/s41467-022-32230-2.
Life-long brain function and mental health are critically determined by developmental processes occurring before birth. During mammalian pregnancy, maternal cells are transferred to the fetus. They are referred to as maternal microchimeric cells (MMc). Among other o …
3D pose estimation enables virtual head-fixation in freely moving rats
Neuron. 2022 Jul 6;110(13):2080-2093.e10. doi: 10.1016/j.neuron.2022.04.019. Epub 2022 May 23.
The impact of spontaneous movements on neuronal activity has created the need to quantify behavior. We present a versatile framework to directly capture the 3D motion of freely definable body points in a marker-free manner with high precision and reliability. Combin …
Prefrontal pyramidal neurons are critical for all phases of working memory
Cell Rep. 2022 Apr 12;39(2):110659. doi: 10.1016/j.celrep.2022.110659.
The prefrontal cortex (PFC) is essential for working memory (WM) and has primarily been viewed as being responsible for maintaining information over a delay, but it is unclear whether it also plays a more general role during WM. …Pyramidal neuron ens …
Multichannel optogenetics combined with laminar recordings for ultra-controlled neuronal interrogation
Topographically organized representation of space and context in the medial prefrontal cortex
Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2117300119. doi: 10.1073/pnas.2117300119.
Topographical analysis revealed a dorsoventral gradient in the representation of the own position, which runs opposite to the innervation density of hippocampal inputs. Jointly, these results reveal a dynamically emerging and topographically organized …
Introducing the Research Unit 5159 “Resolving the prefrontal circuits of cognitive flexibility
Hanganu-Opatz IL., Diester I.,
Neuroforum, Issue 01 2022